TB Journal Club – March and April

There will be no TB journal club in March. We will be going to the joint UCL/LSHTM World TB Day event on 24 March, instead. See you there!

In April, join us to discuss an interesting American paper attempting to estimate rates of TB reactivation in aggregate as well as subgroups of the population. Latency, progression, molecular typing, model parameterisation and policy implications – it should be good!

Shea et al. Estimated Rate of Reactivation of Latent Tuberculosis Infection in the United States, Overall and by Population Subgroup. Am J Epidemiol. 2014; 179(2): 216–225. [available here]

Presenter – Rein Houben, LSHTM
Chair – Emilia Vynnycky, LSHTM
Venue – Lucas Room (LG81), London School of Hygiene and Tropical Medicine, Keppel Street
Time – 4-5pm on 10 April (followed by drinks in the LSHTM bar)

External attendees should try to arrive a few minutes early, as they will need to sign in. LG81 is on the lower ground floor – maps and directions available here.

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Come to February’s TB Journal Club

Please join us on 25 February at the MRC Clinical Trials Unit to discuss a new study looking at shortened intensified treatment for TB meningitis in children.

Presenter: Anna Turkova

Chair: Patrick Phillips

Paper: van Toorn et al. Short Intensified Treatment in Children with Drug-Susceptible Tuberculous Meningitis. PIDJ [e-publication ahead of print. Available here.]

Time: 12.30 to 13.30 on 25 February 2014

Venue: MRC CTU in room 401

Directions: See http://www.ctu.mrc.ac.uk/about_us/contact_details.aspx. The entrance is opposite Holborn tube station and looks like the entrance to a church building.

External attendees will need to wait at reception and be taken to the meeting room. If you plan to attend, please contact Patrick Phillips on ppp@ctu.mrc.ac.uk so that reception know who is expected.

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December journal club.

Please join us for the last journal club of 2013 on Monday 9th December at 12pm, where we will be discussing a paper that deals with the use of next generation sequencing and the identification of resistance sites in the Mtb genome.  Mince pies will be included….

Presenter: Dimitrios Evangelopoulos

Chair: Prof Timothy D McHugh

Paper: Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis” Nat Genet. 2013 Oct;45(10):1183-9. doi: 10.1038/ng.2747

The paper will be backed up by two more from the same journal:

Nat Genet. 2013 Oct;45(10):1255-60. doi: 10.1038/ng.2735 “Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance” and

Nat Genet. 2013 Oct;45(10):1190-7. doi: 10.1038/ng.2743. “Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes”

In addition, Dimitrios will also mention data from our own paper which is in press on the application of next generation sequencing in Mtb.

Time: 12pm

Venue: Tutorial Room 3 (TR3), Royal Free Hospital, Hampstead

Royal%20Free%20Hospital%20LG%20map

Tutorial Room 3 is on the Lower Ground Floor at the Royal Free Hospital. For a more detailed view, please click on the map. For directions to the Royal Free Hospital, please click here.

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An Analysis With Serious Flaws

In May we discussed a recently published systematic review of DOT. Andrew Nunn and Patrick Phillips wrote to the journal highlighting their concerns. Here is a link to the table of contents for the edition of the journal in which their letter was published (alongside several others with additional concerns and comments) and a rather disappointing response from the authors: http://cid.oxfordjournals.org/content/57/7.toc.

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Results from a randomised controlled trial in India looking at shortening treatment with gatifloxacin or moxifloxacin

Please join us on 12th November when Patrick Phillips will present the results of an RCT in India looking at shortening treatment with gatifloxacin or moxifloxacin and comment on the results of  OFLOTUB presented in Paris.

Presenter: Patrick Phillips

Chair: TBC

Paper: Jawahar, M. S., V. V. Banurekha, et al. (2013). “Randomized clinical trial of thrice-weekly 4-month moxifloxacin or gatifloxacin containing regimens in the treatment of new sputum positive pulmonary tuberculosis patients.” PLoS One 8(7): e67030.

Time: 2:00 – 13:00 on 12th November

Venue:  MRC CTU in room 401

Directions: See http://www.ctu.mrc.ac.uk/about_us/contact_details.aspx. The entrance is opposite Holborn tube station and looks like the entrance to a church building.

External attendees will need to wait at reception and be taken to the meeting room. If you plan to attend, please contact Patrick Phillips on ppp@ctu.mrc.ac.uk so that reception know who is expected.

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September journal club: High dose rifampicin for TB meningitis

After a break for the summer, please join us for the first North London TB journal club this academic year at 4pm 27th September 2013 with continuing discussions to take place in the LSHTM bar from 5pm.

Presenter: Anna Checkley

Chair: Alison Grant

Paper: Ruslami R, Ganiem AR, Dian S, Apriani L, Achmad TH, van der Ven AJ, Borm G, Aarnoutse RE, van Crevel R. Intensified regimen containing rifampicin and moxifloxacin for tuberculous meningitis: an open-label, randomised controlled phase 2 trial. Lancet Infect Dis. 2013 Jan;13(1):27-35.

Time: 4pm 27th September 2013.

Venue: Globe Room, London School of Hygiene and Tropical Medicine.

Directions: Download a map here. Walk straight through the foyer through a set of double doors into the Manson Foyer, continue straight through another set of double doors into a corridor, continue straight across in through a final set of double doors and the glass-walled Globe Room is in front of you.

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North London TB Journal Club is on a summer break…

…please check back here soon for details of our next meeting, which will be held in September.

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