Letter now published in AJE

Following discussions at April’s Journal Club, we submitted a letter to the American Journal of Epidemiology. The letter has now been published and can be accessed here. The next Journal Club will be at LSHTM in September.

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Summer break

TB Journal Club is now on a summer break. Our next meeting will be in September 2014. If you would like to watch good discussions about TB before then, we recommend the videos taken at the 2014 LSHTM/UCL World TB Day Symposium.

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Come to June’s TB Journal Club

Please join us at the Royal Free Hospital in June. We will be discussing a paper that attempts to quantify the advantages GeneXpert can bring over empiric treatment in low burden settings, with respect to over treatment and unnecessary rehousing or contact tracing.

Paper: Davis et al. Impact of GeneXpert MTB/RIF® on Patients and Tuberculosis Programs in a Low-Burden Setting: A Hypothetical Trial. Am J Respir Crit Care Med 2014 [Epub ahead of print, available here].

Presenter: Tino Capocci, Research Registrar in Respiratory Medicine, Royal Free Hospital.

Chair: Marc Lipman, Department of Medicine, UCL

Time: 4-5pm, Thursday 26 June (with beers in a local pub afterwards).

Venue: Tutorial Room 1 (TR1), Lower Ground Floor, Royal Free Hospital.

Royal Free Hospital LG map

Tutorial Room 1 is on the Lower Ground Floor at the Royal Free Hospital. For a more detailed view, please click on the map. For directions to the Royal Free Hospital, please click here.

 

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May’s Journal Club

Please join us for North London TB Journal Club in May.

Andrews et al. Integrating social contact and environmental data in evaluating tuberculosis transmission in a South African township. J Infect Dis 2014 [Epub ahead of print].

Presenter: Dr Tom Yates, Research Department of Infection and Population Health, UCL.

Chair: Prof Ibrahim Abubakar, Centre for Infectious Disease Epidemiology, UCL.

Time: 16.00-17.00 on 2 May 2014.

Venue: MSc Room, 4th Floor, Mortimer Market Centre.

Directions: The Mortimer Market Centre is in a courtyard off Capper Street, close to Tottenham Court Road. Turn right at the top of the stairs (or out of the lifts) and press the buzzer to be let through the double doors.

Is exposure to CO2 a reasonable proxy for exposure to TB? Is it safe to go to work or take the bus? How should we best attempt to answer such questions? Join us to discuss an interesting paper on TB transmission in Cape Town. You can access the paper here.

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TB Journal Club – March and April

There will be no TB journal club in March. We will be going to the joint UCL/LSHTM World TB Day event on 24 March, instead. See you there!

In April, join us to discuss an interesting American paper attempting to estimate rates of TB reactivation in aggregate as well as subgroups of the population. Latency, progression, molecular typing, model parameterisation and policy implications – it should be good!

Shea et al. Estimated Rate of Reactivation of Latent Tuberculosis Infection in the United States, Overall and by Population Subgroup. Am J Epidemiol. 2014; 179(2): 216–225. [available here]

Presenter – Rein Houben, LSHTM
Chair – Emilia Vynnycky, LSHTM
Venue – Lucas Room (LG81), London School of Hygiene and Tropical Medicine, Keppel Street
Time – 4-5pm on 10 April (followed by drinks in the LSHTM bar)

External attendees should try to arrive a few minutes early, as they will need to sign in. LG81 is on the lower ground floor – maps and directions available here.

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Come to February’s TB Journal Club

Please join us on 25 February at the MRC Clinical Trials Unit to discuss a new study looking at shortened intensified treatment for TB meningitis in children.

Presenter: Anna Turkova

Chair: Patrick Phillips

Paper: van Toorn et al. Short Intensified Treatment in Children with Drug-Susceptible Tuberculous Meningitis. PIDJ [e-publication ahead of print. Available here.]

Time: 12.30 to 13.30 on 25 February 2014

Venue: MRC CTU in room 401

Directions: See http://www.ctu.mrc.ac.uk/about_us/contact_details.aspx. The entrance is opposite Holborn tube station and looks like the entrance to a church building.

External attendees will need to wait at reception and be taken to the meeting room. If you plan to attend, please contact Patrick Phillips on ppp@ctu.mrc.ac.uk so that reception know who is expected.

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December journal club.

Please join us for the last journal club of 2013 on Monday 9th December at 12pm, where we will be discussing a paper that deals with the use of next generation sequencing and the identification of resistance sites in the Mtb genome.  Mince pies will be included….

Presenter: Dimitrios Evangelopoulos

Chair: Prof Timothy D McHugh

Paper: Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis” Nat Genet. 2013 Oct;45(10):1183-9. doi: 10.1038/ng.2747

The paper will be backed up by two more from the same journal:

Nat Genet. 2013 Oct;45(10):1255-60. doi: 10.1038/ng.2735 “Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance” and

Nat Genet. 2013 Oct;45(10):1190-7. doi: 10.1038/ng.2743. “Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes”

In addition, Dimitrios will also mention data from our own paper which is in press on the application of next generation sequencing in Mtb.

Time: 12pm

Venue: Tutorial Room 3 (TR3), Royal Free Hospital, Hampstead

Royal%20Free%20Hospital%20LG%20map

Tutorial Room 3 is on the Lower Ground Floor at the Royal Free Hospital. For a more detailed view, please click on the map. For directions to the Royal Free Hospital, please click here.

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