World TB Day Event

The UCL/LSHTM World TB Day event will be a day long symposium held on 24 March at the Institute of Child Health. Details will be announced shortly on the TB Centre and UCL-TB websites. It should be good. The next TB journal club will be at the Royal Free Hospital in April.

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Come to February’s TB Journal Club

Why does HIV so dramatically increase susceptibility to TB? Why do HIV positive people remain more susceptible once established on antiretrovirals? Join us to learn more about alveolar macrophages, T cells and the immune response to mycobacteria.

Paper: Jambo et al. Asymptomatic HIV-infected individuals on antiretroviral therapy exhibit impaired lung CD4(+) T-cell responses to mycobacteria. Am J Respir Crit Care Med 2014; 190(8): 938-47 [available here].
Presenter: James Brown, University College London
Chair: Marc Lipman, University College London
Time: 4-5pm, 5 February 2015
Venue: Tutorial Room 1, lower ground floor, Royal Free Hospital.

Tutorial Room 1 is on the Lower Ground Floor at the Royal Free Hospital. For a more detailed view, please click on the map []. For directions to the Royal Free Hospital, please click here [].

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Come to January’s TB Journal Club

In 2014 the Global Burden of Disease published an alternative set of estimates for TB mortality and incidence in the Lancet, suggesting that the global burden and trends were different from those estimated by WHO. Who is right, or less wrong? How should one go about making such estimates, and how should methods and results be described?

Paper: Murray et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384(14): 1005-1070 (available here).
Presenter: Rein Houben, TB Modelling Group, LSHTM
Chair: Richard White, TB Modelling Group, LSHTM
Time: 4-5pm on Monday 19 January (drinks afterwards in the Pumphandle Bar)
Venue: Lucas Room, LSHTM, Keppel Street

The Lucas Room is on the lower ground floor. Please try to arrive a few minutes early, as visitors will need to sign in.

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Come to December’s TB Journal Club

Can M. tuberculosis accumulate mutations in bursts? If so, what does this mean for molecular epidemiology? Join us to discuss sequencing, evolution, transmission chains and MTB’s molecular clock.

Paper: Pérez-Lago et al. Whole genome sequencing analysis of intrapatient microevolution in Mycobacterium tuberculosis: potential impact on the inference of tuberculosis transmission. J Infect Dis 2014; 209(1): 98-108. (available here)
Presenter: Hollie Hatherell, Centre for Infectious Disease Epidemiology, UCL
Chair: Ibrahim Abubakar, Centre for Infectious Disease Epidemiology, UCL
Time: 4-5pm, 17 December 2014 (pub afterwards)
Venue: Duncan Catterall Seminar Room, Mortimer Market Centre

The Duncan Catterall Seminar Room is in the basement of the Mortimer Market Centre, which is off Capper Street (details here). All welcome.

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M.tb Transmission 2014

In place of November’s Journal Club, there is a day long meeting on M.tb transmission…

Date: Tuesday 11 November 2014
Time: 9:00 am 5:30 pm
Venue: John Snow Lecture Theatre, LSHTM, Keppel Street, London, WC1E 7HT, UK

**Register for free via Eventbrite.**

The day will be made up of talks, lively debates, and small group discussions. The topics covered will all relate to TB transmission including basic science, mathematical modelling, healthy design, epidemiology and intervention studies.

This event will be free to attend but attendees must register online. The event is being run thanks to generous support from the TB Modelling and Analysis Consortium, LSHTM TB Centre, UCL-TB, and the UCL Population Health Domain.

We are excited to have some great people joining us including,

  • Allan Bennett, Porton Down
  • Josie Bryant, Sanger Centre/UCL
  • Ted Cohen, Yale University
  • Pete Dodd, CREATE Consortium
  • David Dowdy, Johns Hopkins University
  • Rod Escombe, Imperial College
  • Helen Ayles, ZAMBART/LSHTM
  • Frank Cobelens, KNCV Foundation
  • Michael Kimerling, Gates Foundation
  • Charles Mgone, EDCTP
  • Jimmy Whitworth, Wellcome Trust
  • Robin Wood, Desmond Tutu HIV Centre
  • and faculty from both UCL and LSHTM.

If you have any questions, please email

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(Micro)biology in Bloomsbury

October’s TB Journal Club will focus on a paper attempting to answer some fundamental questions about the biology of TB and similar pathogens. How do intracellular bacteria, such as M. tuberculosis, survive for decades within cells? What adaptations do host cell and bacteria go through? How can we study this?

Paper: Vazquez et al. Experimental selection of long-term intracellular mycobacteria. Cell Microbiol 2014; 16(9): 1425-40. (available here)

Presenter: Karolina Witt, QMUL

Chair: Tim McHugh, Centre for Clinical Microbiology, UCL

Time: 1-2pm on Thursday 23 October

Venue: Duncan Catterall Seminar Room, Mortimer Market Centre

The Duncan Catterall Seminar Room is in the basement of the Mortimer Market Centre, which is off Capper Street (details here). All welcome.

** If you are interested in this, you may be interested in a day long meeting about MTB Transmission on the 11 November – you can register here **

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On 30 September, we’ll be discussing the REMoxTB Trial

Please join us on 30 September at the MRC Clinical Trials Unit to discuss the role of fluoroquinolones in TB treatment and the results of the REMoxTB Study.

Presenter: Patrick Phillips

Paper: Gillespie et al. Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis. N Engl J Med 2014, published online ahead of print. Available here.

Time: 1230 til 1330 on Tuesday 30 September.

Venue: Rooms 2 and 3, 4th floor, MRC CTU. **Note room change**

Directions: See The entrance is opposite Holborn tube station and looks like the entrance to a church building.

External attendees will need to wait at reception and be taken to the meeting room. If you plan to attend, please contact Patrick Phillips (new email address – so that reception know who is expected. Please also arrive promptly to ensure access to the building.

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