The next journal club will take place on Tuesday the 12th May at 4pm in The South Wing G12 Council Room at UCL and will be led by Dr Helen Donoghue on the publication of her recent paper in Nature “Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe” www.nature.com/ncomms/2015/150407/ncomms7717/abs/ncomms7717.html
We will be going to a pub nearby for drinks afterwards – please join us.
Places are free but please register so we can keep in touch, and we’ll send you a map of the location of the room.
Book now at: www.eventbrite.co.uk/e/north-london-tb-journal-club-may-2015-tickets-16628223464
The April journal club has been postponed to the 12th of May from 4-5pm at UCL, Gower Street.
UCL and LSHTM are organising a day long symposium on 24 March – ‘World TB Day 2015: What do we need to know to reach, treat and cure everyone with TB?’
For details and to register, please click here. The next meeting of North London TB Journal Club will be at the Royal Free in April.
The UCL/LSHTM World TB Day event will be a day long symposium held on 24 March at the Institute of Child Health. Details will be announced shortly on the TB Centre and UCL-TB websites. It should be good. The next TB journal club will be at the Royal Free Hospital in April.
Why does HIV so dramatically increase susceptibility to TB? Why do HIV positive people remain more susceptible once established on antiretrovirals? Join us to learn more about alveolar macrophages, T cells and the immune response to mycobacteria.
Paper: Jambo et al. Asymptomatic HIV-infected individuals on antiretroviral therapy exhibit impaired lung CD4(+) T-cell responses to mycobacteria. Am J Respir Crit Care Med 2014; 190(8): 938-47 [available here].
Presenter: James Brown, University College London
Chair: Marc Lipman, University College London
Time: 4-5pm, 5 February 2015
Venue: Tutorial Room 1, lower ground floor, Royal Free Hospital.
Tutorial Room 1 is on the Lower Ground Floor at the Royal Free Hospital. For a more detailed view, please click on the map [https://northlondontb.files.wordpress.com/2014/05/royal-free-hospital-lg-map.jpg]. For directions to the Royal Free Hospital, please click here [https://www.royalfree.nhs.uk/contact-us/getting-to-our-hospitals/how-to-get-to-royal-free-hospital/].
In 2014 the Global Burden of Disease published an alternative set of estimates for TB mortality and incidence in the Lancet, suggesting that the global burden and trends were different from those estimated by WHO. Who is right, or less wrong? How should one go about making such estimates, and how should methods and results be described?
Paper: Murray et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384(14): 1005-1070 (available here).
Presenter: Rein Houben, TB Modelling Group, LSHTM
Chair: Richard White, TB Modelling Group, LSHTM
Time: 4-5pm on Monday 19 January (drinks afterwards in the Pumphandle Bar)
Venue: Lucas Room, LSHTM, Keppel Street
The Lucas Room is on the lower ground floor. Please try to arrive a few minutes early, as visitors will need to sign in.
Can M. tuberculosis accumulate mutations in bursts? If so, what does this mean for molecular epidemiology? Join us to discuss sequencing, evolution, transmission chains and MTB’s molecular clock.
Paper: Pérez-Lago et al. Whole genome sequencing analysis of intrapatient microevolution in Mycobacterium tuberculosis: potential impact on the inference of tuberculosis transmission. J Infect Dis 2014; 209(1): 98-108. (available here)
Presenter: Hollie Hatherell, Centre for Infectious Disease Epidemiology, UCL
Chair: Ibrahim Abubakar, Centre for Infectious Disease Epidemiology, UCL
Time: 4-5pm, 17 December 2014 (pub afterwards)
Venue: Duncan Catterall Seminar Room, Mortimer Market Centre
The Duncan Catterall Seminar Room is in the basement of the Mortimer Market Centre, which is off Capper Street (details here). All welcome.