October’s TB Journal Club will focus on a paper attempting to answer some fundamental questions about the biology of TB and similar pathogens. How do intracellular bacteria, such as M. tuberculosis, survive for decades within cells? What adaptations do host cell and bacteria go through? How can we study this?
Paper: Vazquez et al. Experimental selection of long-term intracellular mycobacteria. Cell Microbiol 2014; 16(9): 1425-40. (available here)
Presenter: Karolina Witt, QMUL
Chair: Tim McHugh, Centre for Clinical Microbiology, UCL
Time: 1-2pm on Thursday 23 October
Venue: Duncan Catterall Seminar Room, Mortimer Market Centre
The Duncan Catterall Seminar Room is in the basement of the Mortimer Market Centre, which is off Capper Street (details here). All welcome.
** If you are interested in this, you may be interested in a day long meeting about MTB Transmission on the 11 November – you can register here **
Please join us on 30 September at the MRC Clinical Trials Unit to discuss the role of fluoroquinolones in TB treatment and the results of the REMoxTB Study.
Presenter: Patrick Phillips
Paper: Gillespie et al. Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis. N Engl J Med 2014, published online ahead of print. Available here.
Time: 1230 til 1330 on Tuesday 30 September.
Venue: Rooms 2 and 3, 4th floor, MRC CTU. **Note room change**
Directions: See http://www.ctu.mrc.ac.uk/about_us/contact_details/. The entrance is opposite Holborn tube station and looks like the entrance to a church building.
External attendees will need to wait at reception and be taken to the meeting room. If you plan to attend, please contact Patrick Phillips (new email address – Patrick.email@example.com) so that reception know who is expected. Please also arrive promptly to ensure access to the building.
On 11 November there will be a special day long meeting on TB transmission at LSHTM. This meeting, which will be free to attend, is being organised jointly by LSHTM and UCL. Some very exciting speakers have already been confirmed. Details are available here. More soon.
Following discussions at April’s Journal Club, we submitted a letter to the American Journal of Epidemiology. The letter has now been published and can be accessed here. The next Journal Club will be at LSHTM in September.
TB Journal Club is now on a summer break. Our next meeting will be in September 2014. If you would like to watch good discussions about TB before then, we recommend the videos taken at the 2014 LSHTM/UCL World TB Day Symposium.
Please join us at the Royal Free Hospital in June. We will be discussing a paper that attempts to quantify the advantages GeneXpert can bring over empiric treatment in low burden settings, with respect to over treatment and unnecessary rehousing or contact tracing.
Paper: Davis et al. Impact of GeneXpert MTB/RIF® on Patients and Tuberculosis Programs in a Low-Burden Setting: A Hypothetical Trial. Am J Respir Crit Care Med 2014 [Epub ahead of print, available here].
Presenter: Tino Capocci, Research Registrar in Respiratory Medicine, Royal Free Hospital.
Chair: Marc Lipman, Department of Medicine, UCL
Time: 4-5pm, Thursday 26 June (with beers in a local pub afterwards).
Venue: Tutorial Room 1 (TR1), Lower Ground Floor, Royal Free Hospital.
Tutorial Room 1 is on the Lower Ground Floor at the Royal Free Hospital. For a more detailed view, please click on the map. For directions to the Royal Free Hospital, please click here.
Please join us for North London TB Journal Club in May.
Andrews et al. Integrating social contact and environmental data in evaluating tuberculosis transmission in a South African township. J Infect Dis 2014 [Epub ahead of print].
Presenter: Dr Tom Yates, Research Department of Infection and Population Health, UCL.
Chair: Prof Ibrahim Abubakar, Centre for Infectious Disease Epidemiology, UCL.
Time: 16.00-17.00 on 2 May 2014.
Venue: MSc Room, 4th Floor, Mortimer Market Centre.
Directions: The Mortimer Market Centre is in a courtyard off Capper Street, close to Tottenham Court Road. Turn right at the top of the stairs (or out of the lifts) and press the buzzer to be let through the double doors.
Is exposure to CO2 a reasonable proxy for exposure to TB? Is it safe to go to work or take the bus? How should we best attempt to answer such questions? Join us to discuss an interesting paper on TB transmission in Cape Town. You can access the paper here.