Paper: Zak et al. A blood RNA signature for tuberculosis disease risk: a prospective cohort study. The Lancet 2016 Jun 4; 387: 2312-22 [Paper here Zak Lancet 2016]
Presenter: Dr Jennifer Roe, Division of Infection and Immunity, UCL
Chair: Dr Maddy Noursadeghi, Division of Infection and Immunity, UCL
Time: 1-2pm, Wednesday 26th April 2017
Venue: Foyer Seminar Room 2, Cruciform Building, UCL
[Map here http://www.ucl.ac.uk/maps/cruciform-foyer-seminar-room-2 , Take door on left immediately after Cruciform front reception/security, up stairs one floor and room is straight ahead]
Please join us this month to discuss a paper on possible blood biomarkers (gene expression (RNA-derived) ‘risk’ signatures) to predict progression of latent M.tb infection to active disease up to 18 months before pulmonary tuberculosis clinically manifests.
All are welcome.
Paper: Shen et al. Recurrent tuberculosis in an urban area in China: Relapse or exogenous reinfection? Tuberculosis 2017; 103: 97-104 [available here].
Presenter: Lara Gosce, Institute for Global Health, UCL
Chair: Tom Yates, Institute for Global Health, UCL
Time: 1-2pm, Friday 24 February 2017
Venue: Room 2.18, Chadwick Building, UCL [map here]
Please join us this month to discuss a paper on TB recurrence in Shanghai, focusing on the relative contributions made by relapse versus exogenous reinfection. How do we tease these apart? Should China prioritise efforts to improve treatment adherence or to interrupt transmission? All welcome.
Time: 4-5pm on Wednesday 25 January 2017
Venue: Room 2.18, Chadwick Building, University College London [map here]
Speaker: Giovanni Satta
Chair: Tim McHugh
Casali N, Broda A, Harris SR, Parkhill J, Brown T, Drobniewski F. Whole Genome Sequence Analysis of a Large Isoniazid-Resistant Tuberculosis Outbreak in London: A Retrospective Observational Study. PLoS Med 2016; 13(10): e1002137. [available here]
Satta G, Witney AA, Shorten RJ, Karlikowska M, Lipman M, McHugh TD. Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance. BMC Med 2016; 14(1): 117. [available here]
Happy New Year! This month, North London TB Journal Club will discuss two recent papers on the London isoniazid resistant TB outbreak. We look forward to seeing you there – all welcome.
Presenter: Julie Demaret
Chair: Adrian Martineau
Time: 4-5pm, Thursday 24 November 2016
Venue: Room 1.32, Garrod Building, Turner Street, E1 2AD [map here]
Paper: Malherbe et al. Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure. Nat Med 2016; 22(10): 1094-1100. [available here]
Please join us to discuss an interesting paper exploring radiological and molecular correlates of TB cure. What does cure mean? Are all bacilli killed? How might the way we define treatment response influence the way we test new drugs and regimens against Mycobacterium tuberculosis?
This month, we will be discussing a paper that attempts to estimate the number of TB cases being managed in the private sector in India.
Paper: Arinaminpathy et al. The number of privately treated tuberculosis cases in India: an estimation from drug sales data. Lancet Infectious Disease, 2016: published online ahead of print.
Presented by Marc Lipman
Time: 4-5pm, Thursday 13 October 2016
Venue: Tutorial Room 1, lower ground floor, Royal Free Campus, UCL Medical School
All welcome. A map of the campus is available here. Instructions about how to get to the Royal Free are available here. The paper is available here and the supplemental materials are available here.
Please join us for our first meeting of the 2016/17 academic year, which will be hosted by the MRC Clinical Trials Unit.
Speaker – Riya Moodley
Chair – Patrick Phillips
Time – 12.30 til 13.30 on Tuesday 27 September
Venue – Aviation House
At the meeting, we will be discussing the 2016 update to the WHO treatment guidelines for drug-resistant tuberculosis. You can access the relevant documents here…
– the guidelines
– the factsheet
– frequently asked questions
Were the right drugs promoted and demoted? Was the WHO correct to conditionally recommend use of shorter Bangladesh-style regimens in certain circumstances? How should children be treated? What is the role for surgery in managing drug-resistant TB?
If you plan to attend, please email email@example.com before the meeting. Please plan to arrive 5-10 minutes early to allow time to clear security.
North London TB Journal Club is on a summer break during July and August. However, we will be back in September 2016 under new management – more details soon. In the meantime, you may like to catch up with videos of previous TB events held in North London – the M.tb Transmission Meeting, the World TB Day 2016 event, or the recent RSTMH meeting on the End TB Strategy.