Topic: Is rifapentine all it’s cracked up to be?
Sterling et al. Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection. N Engl J Med 2011; 365: 2155-66.
Presenter: Rob Aldridge, Research Department of Infection and Population Health, UCL
Chair: Tim McHugh, Centre for Clinical Microbiology, Royal Free Campus, UCL
Time: 9am til 10am, Thursday 15 November 2012
Venue: Seminar Room 2, Upper 3rd Floor, Royal Free Hospital (which is hard to find – for directions, click here)
There’s lots of interest in shorter regimes for treating latent TB. Sterling’s paper in NEJM last December got many people excited – a big study showing better completion and less progression to active disease with weekly rifapentine-isoniazid than with 9 months of daily isoniazid.
Should we change our practice?
Does it matter that treatment support differed in the two arms of the study?
Should they have attempted blinding?
Could you take 15 or 16 tablets in one go!?
Join us to discuss the study and broader issues around the treatment of latent TB infection.
The paper is available here – Sterling et al, 2011.