Please join us for the last journal club of 2013 on Monday 9th December at 12pm, where we will be discussing a paper that deals with the use of next generation sequencing and the identification of resistance sites in the Mtb genome. Mince pies will be included….
Presenter: Dimitrios Evangelopoulos
Chair: Prof Timothy D McHugh
Paper: “Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis” Nat Genet. 2013 Oct;45(10):1183-9. doi: 10.1038/ng.2747
The paper will be backed up by two more from the same journal:
Nat Genet. 2013 Oct;45(10):1255-60. doi: 10.1038/ng.2735 “Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance” and
Nat Genet. 2013 Oct;45(10):1190-7. doi: 10.1038/ng.2743. “Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes”
In addition, Dimitrios will also mention data from our own paper which is in press on the application of next generation sequencing in Mtb.
Venue: Tutorial Room 3 (TR3), Royal Free Hospital, Hampstead
Tutorial Room 3 is on the Lower Ground Floor at the Royal Free Hospital. For a more detailed view, please click on the map. For directions to the Royal Free Hospital, please click here.
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