North London TB JC and UCL-Tb look forward to welcoming you to October’s JC, where we will discuss the recent publication in Nature, IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure – Lu et al, Nature Medicine 2019
Synopsis: In this paper, Lu and colleagues report detailed investigation of a Ugandan cohort highly exposed to M. tuberculosis, but who repeatedly test negative using conventional latent TB diagnostics. Intriguingly, they find that these individuals demonstrate interferon gamma-independent adaptive responses to M. tb, in the form of both T cell and antibody responses. These findings challenge the notion of innate clearance, with wide ranging implications for latent TB and vaccine efficacy studies.
Full details can be found on the ‘Up Coming Events Page’
North London TB Journal Club 