Monthly Archives: November 2019

November: Is ACF effective for high-prevalence settings?: Outcomes from the Vietnam Cluster RCT 2014–8

 Join us at LSHTM on November 27th to discuss the following paper. Full details can be found on the ‘Upcoming Events’ page.

Marks et al. performed a cluster-randomized, controlled trial in a province in Vietnam, to compared the effectiveness of ACF and PCF for reducing the prevalence of tuberculosis. Prevalence for persons 15 years of age or older reduced in both arms but there was a greater reduction in the intervention arm. Intriguingly, there was no significant difference in  prevalence of tuberculosis infection in children aged 5 at the end of the trial. This trial makes an important contribution to the ongoing debate on whether ACF is an effective tool for decreasing TB prevalence and transmission.

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