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October ’19: IGRAs…are they fit for purpose and do resistors really exist?

North London TB JC and UCL-Tb look forward to welcoming you to October’s JC, where we will discuss the recent publication in Nature, IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure – Lu et al, Nature Medicine 2019

Synopsis: In this paper, Lu and colleagues report detailed investigation of a Ugandan cohort highly exposed to M. tuberculosis, but who repeatedly test negative using conventional latent TB diagnostics. Intriguingly, they find that these individuals demonstrate interferon gamma-independent adaptive responses to M. tb, in the form of both T cell and antibody responses. These findings challenge the notion of innate clearance, with wide ranging implications for latent TB and vaccine efficacy studies.

Full details can be found on the ‘Up Coming Events Page’

 

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September ’19: Can anyone be successfully treated with a 4-month regimen?

September Journal Club at the MRC CTU : “A patient-level pooled analysis of treatment shortening regimens for drug-susceptible pulmonary tuberculosis” – Imperial et al, Nature Medicine, November 2018

Three recent trials using 4-month, moxifloxacin containing regimens failed to show non-inferiority in comparison to 6 months of standard HRZE therapy in patients with smear positive, drug sensitive tuberculosis. In this paper Imperial and colleagues re-analysed data from 3,405 participants in these trials to identify populations eligible for 4-month treatment, define phenotypes that are hard to treat and evaluate the impact of adherence and dosing strategy on outcomes.

Please join us at the MRC CTU for a critical discussion of this paper and debate around whether it is time to reconsider the one-size fits all approach to TB management in favour of a stratified medicine approach.

Click here for full details of the event

 

 

 

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Tb Journal Club is on Summer Break

North London TB Journal Club is on summer break in August 2019. However, we will be back in September 2019, with a new schedule for the coming year. Details to follow soon.

We say goodbye and good luck in the future to Dr Naomi Walker, who has worked hard to organise this years events and welcome Dr Robin Basu Roy, who will join Dr Oshani Dissanayake in organising the journal clubs for the Academic year 2019-20.

In the meantime, you may be interested in some of the following:

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Welcome!

The North London TB Journal Club continues to host monthly meeting across our regular sites. A full calendar will be available for the Academic year of 2018-2019

Please Click on the link or go to the ‘upcoming events‘ page, for full details of all upcoming events.

We look forward to meeting you all in October!

For further information, queries or enquiries regarding joining our mailing list please see ‘contact ‘ page of the website.

 

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Come to February’s TB Journal Club

Paper: Shen et al. Recurrent tuberculosis in an urban area in China: Relapse or exogenous reinfection? Tuberculosis 2017; 103: 97-104 [available here].

Presenter: Lara Gosce, Institute for Global Health, UCL

Chair: Tom Yates, Institute for Global Health, UCL

Time: 1-2pm, Friday 24 February 2017

Venue: Room 2.18, Chadwick Building, UCL [map here]

 

Please join us this month to discuss a paper on TB recurrence in Shanghai, focusing on the relative contributions made by relapse versus exogenous reinfection. How do we tease these apart? Should China prioritise efforts to improve treatment adherence or to interrupt transmission? All welcome.

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January’s TB Journal Club

Time: 4-5pm on Wednesday 25 January 2017

Venue: Room 2.18, Chadwick Building, University College London [map here]

Speaker: Giovanni Satta

Chair: Tim McHugh

Papers:

Casali N, Broda A, Harris SR, Parkhill J, Brown T, Drobniewski F. Whole Genome Sequence Analysis of a Large Isoniazid-Resistant Tuberculosis Outbreak in London: A Retrospective Observational Study. PLoS Med 2016; 13(10): e1002137. [available here]

Satta G, Witney AA, Shorten RJ, Karlikowska M, Lipman M, McHugh TD. Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance. BMC Med 2016; 14(1): 117. [available here]

Happy New Year! This month, North London TB Journal Club will discuss two recent papers on the London isoniazid resistant TB outbreak. We look forward to seeing you there – all welcome.

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Come to November’s TB Journal Club at QMUL

Presenter: Julie Demaret

Chair: Adrian Martineau

Time: 4-5pm, Thursday 24 November 2016

Venue: Room 1.32, Garrod Building, Turner Street, E1 2AD [map here]

Paper: Malherbe et al. Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure. Nat Med 2016; 22(10): 1094-1100. [available here]

Please join us to discuss an interesting paper exploring radiological and molecular correlates of TB cure. What does cure mean? Are all bacilli killed? How might the way we define treatment response influence the way we test new drugs and regimens against Mycobacterium tuberculosis?

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