February 2021:
Host: MRC Gambia for LSHTM
Date: Thursday 25th February
Paper: CORTIS Trial – Scriba TJ, Fiore-Gartland A, Penn-Nicholson A, et al. Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial. The Lancet. Infectious Diseases. 2021 Jan. DOI: 10.1016/s1473-3099(20)30914-2.
Postponement due to Covid-19
October 2020:
Host: The Francis Crick Institute
Date: Thursday 29th October
Paper: Conradie F, et al. Treatment of Highly Drug-Resistant Pulmonary Tuberculosis. N Engl J Med. 2020 Mar 5;382(10):893-902
September 2020:
Host: Imperial College London
Date: Thursday 24th September
Papers:
Motta et al. Tuberculosis, COVID-19 and migrants: Preliminary analysis of deaths occurring in 69 patients from two cohorts. Pulmonology 2020;26(4):233-40
Stochino et al. Clinical characteristics of COVID-19 and active tuberculosis co-infection in an Italian reference hospital. Eur Respir J 2020;56(1):2001708
Tadolini et al. Active tuberculosis, sequalae and COVID-19 co-infection: first cohort of 49 cases. Eur Respir J 2020;56(1):2001398
Liu et al. Severe COVID-19 cases with a history of active or latent tuberculosis. Int J Tuberc Lung Dis 2020;24(7):747-9
Postponement due to Covid-19
February 2020:
Speaker: Dr. Ilaria Motta, TB-PRACTECAL and EndTB clinical trials medical monito
Date and Time: Wednesday 19th February, 2020
Venue: MSF
Paper: Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis
November 2019:
Speaker: Madeline Clarkson, Alexandra Richards, Kiesha Prem. Chaired by Richard White
Date and Time: Wednesday 27th November 2019
Venue: LSHTM
Paper: Community-wide screening for tuberculosis in a high-prevalence setting. Marks et al, NEJM Oct 2019.
October 2019:
Speaker: Rishi Gupta and Maddy Noursadeghi
Date and Time: Thursday 17th October 2019
Venue: UCL
Paper: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure – Lu et al, Nature Medicine 201
September 2019
Speaker:
Date and Time:
Venue:
Paper:
August 2019 – Summer break
July 2019
Speaker: Dr Ilaria Motta
Date and Time: Tuesday 16th July 2019, 16:00
Venue: MSF
Paper: Broger T et al, Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study. Lancet Infect Dis 2019
June 2019
Speaker: Dr Naomi Walker
Date and Time: Friday 28th June 2019, 16:00-17:00
Venue: LSHTM
Paper: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Strain etc Al. Nature 2019
May 2019
Speaker: Dr Kate Gaskell
Date and Time: Monday 20th May, 2019, 16-1700
Venue: LSHTM
Paper: Sone Month of Rifapentine plus Isoniazid to prevent His related Tuberculosis
March 2019
Speaker: Dr Marc Lipman
Date and Time: Monday 18th March
Venue: UCL
Paper: Should NICE reconsider the 2016 UK guidelines on TB contact tracing? A cost-effectiveness analysis of contact investigation in London
February 2019
No event
January 2019 – Hosted by UCL Department of Infection and Immunity
Speaker: Dr Emily Shaw
Date and Time: Thursday 31st January, 13:00-14:00
Venue: UCL
Paper: Clinical utility of existing and second generation interferon gamma release assays for diagnostic evaluation of tuberculosis: an observational cohort study
December 2018 – Hosted by The MRC Clinical Trials Unit
Speaker: Saiam Ahmed
Date and Time: Thursday 20th Decemeber, 12:30-13:30
Venue: MRC Clinical Trials Unit
Paper: Substitution of Ethambutol with Linezolid during the intensive phase of treatment of pulmonary tuberculosis: a prospective, multi centre, randomised, open-label phase 2 trial.
November 2018 – Hosted by The Francis Crick Institute.
Speaker: Robert Wilkinson
Date and Time: Tuesday 6th November, 13:00-14:00
Venue: The Francis Crick Institute
Paper: Phase 2B Controlled Trial of M27/AS01E Vaccine to Prevent Tuberculosis
October 2018 – Hosted by Medicins Sans Frontieres
Chair: Bern-Thomas Nyang’wa, MSF
Speaker: Dr Catherine Berry, Medical Monitor for TB-PRACTECAL and end TB clinical trials, Manson Unit, MSF
Date and time: Tuesday 16th October, 16:00-17:00
Venue: MSF offices – Chancery Exchange, 10 Furnival Street, EC4A 1AB
Paper: TREATMENT CORRELATES OF SUCCESSFUL OUTCOMES IN PULMONARY MULITDRUG-RESISTANT TUBERCULOSIS: AN INDUVIDUAL PATIENT DATA METANALYSIS.
[Summer Break]
June 2018 – Hosted by UCL-TB
Chair: Marc Lipman, Royal Free Hospital/UCL-TB
Speaker: Helen Stagg, UCL
Date and time: 4:00-5:00pm Wednesday 6th June
Venue: Rockerfeller Building 339, UCL, 21 University St, London WC1E 6DE [map here]
Paper: Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient meta-analysis, F Fregonese et al, Lancet Infectious Disease April 2018 [Available here]
May 2018 hosted by LSHTM
Chair: Katherine Fielding, LSHTM
Speakers: Daniel Grint and Daniel Carter
Date and Time: 1-2pm, Thursday 10th May
Venue: Weston Room, Tavistock Place building of LSHTM, 15-17 Tavistock Place, London, WC1H 9SH [map here]
Paper: Fox et al NEJM 2018 378 3 221- ‘Household-Contact Investigation for Detection of Tuberculosis in Vietnam’ Available here [nejmoa1700209]
April 2018 hosted by LSHTM
Speaker: Ankur Gupta-Wright, LSHTM
Date and Time: 12:30pm-14:00pm, Thursday 26th April
Venue: Room LG8, LSHTM, Keppel Street, London, WC1E 7HT [map here]
Paper: A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study, TM Walker et al, Lancet Infectious Disease April 2018. Available here [PIIS1473309918300045]
March 2018 – no separate meeting – LSHTM/UCL-TB World TB Day Event
February 2018 hosted by Medecins Sans Frontier
Chair: Bern-Thomas Nyang’wa, Medecins Sans Frontieres (PI TB-PRACTECAL)
Speaker: Ilaria Motta (Medical Monitor, TB-PRACTECAL)
Paper: Early safety and efficacy of the combination of bedaquiline and delamanid for the treatment of patients with drug-resistant tuberculosis in Armenia, India, and South Africa: a retrospective cohort study Ferlazzo, Gabriella et al. The Lancet Infectious Diseases Feb 2018 [available here]
January 2018 hosted by UCL-TB
Speaker – Dr Gabriel Pollara
Paper– L Paris, R Magni, F Zaidi et al Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity. Science Translational Medicine 13 Dec 2017: Vol. 9, Issue 420, eaal2807 DOI: 10.1126/scitranslmed.aal2807 [Available here]
eLetter response published following this meet: Pollara Nanocage-based sequestration of urine lipoarabinomannan for diagnosis of subclinical tuberculosis in HIV co-infected patients? Science Translational Medicine 13 Dec 2017:
Vol. 9, Issue 420 (available here)
December 2017 hosted by Royal Free Hospital/UCL-TB
Speaker – Prof Tim McHugh
Paper – Thompson EG et al Host blood RNA signatures predict the outcome of tuberculosis treatment Tuberculosis 2017 Dec;107:48-58 [available here]
October 2017 hosted by Royal Free Hospital with guest chair Gerald Friedland
Presenter-James Brown, Marc Lipman
Paper – Y.L. Xie at al ‘Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis’ N Engl J Med 2017;377:1043-54 [Available here Xie_NEJM_2017]
30 May 2017: ‘Treatment of isoniazid-resistant tuberculosis with first-line drugs: a systematic review and meta-analysis.’ with Patrick Phillips
Paper: Gegia et al Treatment of isoniazid-resistant tuberculosis with first-line drugs: a systematic review and meta-analysis. Lancet Infectious Diseases Volume 17, No. 2, p223-234, February 2017. Full paper available here: http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(16)30407-8/fulltext
Presenter: Dr Patrick Phillips, Institute of Clinical Trials & Methodology, MRC Clinical Trials Unit at UCL
Time: 12:30pm – 13:30pm, Tuesday 30th May 2017
Venue: MRC Clinical Trials Unit at UCL, Aviation House,125 Kingsway, London, WC2B 6NH
26 April 2017: ‘A blood RNA signature for tuberculosis disease risk: a prospective cohort study.’ with Jennifer Roe and Maddy Noursadeghi (details here)
24 March 2017: Joint UCL/LSHTM symposium to mark World TB Day (videos to be made available here)
24 February 2017: ‘Recurrent TB in Shanghai’ with Lara Gosce and Tom Yates (details here)
25 January 2017 – ‘INH resistant TB in London’ with Giovanni Satta and Tim McHugh (details here)
December 2016 – no meeting
24 November 2016 – ‘TB cure’ with Julie Demaret and Adrian Martineau (details here)
13 October 2016 – ‘How much TB is treated in the Indian private sector’ with Marc Lipman (details here)
27 September 2016 – ‘WHO treatment guidelines for drug-resistant tuberculosis’ with Riya Moodley and Patrick Phillips (details here)
[summer break]
14 June 2016 – ‘Weekly rifapentine and isoniazid for treatment of Mycobacterium tuberculosis infection in HIV-coinfected persons’ with Jenna Wills and Conor Tweed (details here)
May 2016 – no meeting
26 April 2016 – ‘Genetic determinants of drug resistance in Mycobacterium tuberculosis and their diagnostic value’ with Fracesc Coll and Helen Stagg (details here)
23 March 2016 – Joint UCL/LSHTM symposium to mark World TB Day (videos available here)
15 February 2016 – ‘Modelling bacillary elimination rates’ with Michael Murphy and Marc Lipman (details here)
27 January 2016 – ‘How long does protection from BCG last?’ with Patrick Nguipdop-Djomo (details here)
December 2015 – no meeting
24th November 2015 – ‘Standardised patients to assess quality of tuberculosis care’ with Conor Tweed (details here)
13 October 2015 – ‘MVA65A and tuberculosis challenge in animals’ with Helen Fletcher (details here)
24 September 2015 – ‘Linezolid for XDR-TB’ with Catherine Berry and Philipp du Cros (details here)
[Summer break]
30 June 2015 – ‘Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resistant pulmonary tuberculosis.’ with Riya Moodley and Patrick Philips (details here)
12 May 2015 – ‘Insights from 18th Century MTB genomes’ with Helen Donoghue (details here)
April 2015 – no meeting
24 March 2015 – World TB Day 2015: What do we need to know to reach, treat and cure everyone with TB?’ A day long symposium at the Institute of Child Health (videos of talks available here)
5 February 2015 – ‘How does HIV increase susceptibility to TB?’ with James Brown and Marc Lipman (details here)
19 January 2015 – ‘How much TB is there?’ with Rein Houben and Richard White (details here)
17 December 2014 – ‘Microevolution, molecular epidemiology and (if you’re lucky) mince pies’ with Hollie Hatherell and Ibrahim Abubakar (details here)
11 November 2014 – we had the UCL/LSHTM M.tb Transmission Meeting, in place of TB journal club (presentations available here)
23 October 2014 – ‘Experimental selection of long-term intracellular mycobacteria‘ with Karolina Witt and Tim McHugh (details here)
30 September 2014 – ‘Four-Month Moxifloxacin-Based Regimens for Drug-Sensitive Tuberculosis’ with Patrick Phillips (details here)
[summer break]
26 June 2014 – ‘GeneXpert vs empiric treatment in low burden settings’ with Tino Capocci and Marc Lipman (details here).
2 May 2014 – ‘Carbon dioxide meters, social contact patterns and TB transmission in a high burden informal settlement’ with Tom Yates and Ibrahim Abubakar (details here)
10 April 2014 – ‘Estimated Rate of Reactivation of Latent Tuberculosis Infection in the United States, Overall and by Population Subgroup’ with Rein Houben and Emilia Vynnycky (details here)
24 March 2014 – ‘World TB Day 2014: Reaching the 3 Million’. Joint LSHTM/UCL event, in place of journal club (presentations available here)
25 February 2014 – ‘Short course intensified treatment for children with drug sensitive TB meningitis’ with Anna Turkova and Patrick Phillips (details here)
January 2014 – no meeting.
9 December 2013 – ‘Next generation sequencing, drug resistance and mince pies’ with Dimitrios Evangelopoulos and Tim McHugh (details here)
12 November 2013 – ‘Results from a randomised controlled trial in India looking at shortening treatment with gatifloxacin or moxifloxacin’ with Patrick Phillips (details here)
October 2013 – no journal club
27 September 2013 – ‘High dose rifampicin for TB meningitis’ with Anna Checkley and Alison Grant (details here)
[summer break]
20 June 2013 – ‘6 versus 36-month isoniazid preventive treatment – which is best?’ with Laura Munoz and Ibrahim Abubakar (details here).
21 May 2013 – Do we really need DOT? ‘A meta-analysis of self-administered versus directly observed therapy effect on microbiologic failure, relapse, and acquired drug resistance in tuberculosis patients.’ with Prof. Andrew Nunn and Patrick Phillips (details here)
29 April 2013 – Linezolid for treatment of chronic extensively drug-resistant tuberculosis with Isobella Honeyborne and Timothy Mchugh (details here)
5 March 2013 – ‘Transmission, outbreaks and whole genome sequencing’ with Jess Mears and Marc Lipman (details here)
11 February 2013 – ‘Modelling TB transmission in Pollsmoor Prison, Cape Town’ with Pete Dodd and Richard White (details here).
31 January 2013 – ‘Promising new regimens or studies of uncertain value?’ with Jurgens Peters and Patrick Phillips (details here)
18 December 2012 – ‘Should we kill all the badgers?’ with Sarah Lou Bailey and Dave Moore (details here)
15 November 2012 – ‘Is rifapentine all it’s cracked up to be?’ with Rob Aldridge and Tim McHugh (details here)
Banner image courtesy of the World Lung Foundation Image Library.
North London TB Journal Club 