Welcome to the Academic Year 2019-20 Schedule
IGRAs…are they fit for purpose and do resistors really exist?
Hosted by UCL-TB
In this paper, Lu and colleagues report detailed investigation of a Ugandan cohort highly exposed to M. tuberculosis, but who repeatedly test negative using conventional latent TB diagnostics. Intriguingly, they find that these individuals demonstrate interferon gamma-independent adaptive responses to M. tb, in the form of both T cell and antibody responses. These findings challenge the notion of innate clearance, with wide ranging implications for latent TB and vaccine efficacy studies.
PAPER: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure – Lu et al, Nature Medicine 2019 [Click here for paper]
PRESENTER: Rishi Gupta and Maddy Noursadeghi
DATE: Thursday 17th October, 2019
VENUE: Foyer Seminar Room 2, The Cruciform Building, Gower Street, London, WC1E 6BT [Click here for Map]